CAS 133242-30-5 Landiolol For Surgical Tachycardia Atrial Fibrillation

CAS 133242-30-5 Landiolol For Surgical Tachycardia Atrial Fibrillation

use
For surgical tachycardia (atrial fibrillation, atrial flutter and sinus tachycardia).

Matters needing attention
Use with caution in patients with cardiogenic shock, hypersensitivity to this product, obvious cardiac insufficiency, degree Ⅱ ~ Ⅲ atV block, and severe sinus bradycardia. Use with caution in patients with cardiac inhibition during surgical anesthesia, bronchial asthma, congestive heart failure, diabetes, elderly patients, hepatic insufficiency, thyroid disease, hypotension, and peripheral vascular disease. Stop the drug slowly to avoid sudden arrest.

Clinical evaluation
During the operation, due to endotracheal intubation and extubation, skin incision and surgical operation and other stimulation to the body, the sympathetic nerve is excited, excessive catecholamines are released, and the heart beat number is increased, which is easy to cause tachycardia arrhythmia. Especially in patients with ischemic heart disease and hypertension, the increase in the number of beats alone will increase the load of the heart, resulting in ischemia of the coronary artery. Landiolol is a drug developed by Chemicalbook for this purpose. Clinical trials have shown that for emergency tachyarrhythmias, such as atrial fibrillation, atrial fibrillation and sinus tachycardia, this product is administered within 1min at 0.125mg/kg, followed by intravenous administration at 0.04mg/(kg·min), and the heart rate significantly slows down 2 to 3min after administration. Tachyarrhythmia can be effectively controlled.

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