Hot Selling 99% CAS 111974-69-7 Quetiapine Pharmaceutical raw materials

Hot Selling 99% CAS 111974-69-7 Quetiapine Pharmaceutical raw materials

antipsychotic
Quetiapine, also known as quetiapine fumarate, quetiapine fumarate, Kevix, Seroquel, is currently used in the clinical treatment of schizophrenia first-line drugs, positive and negative symptoms of schizophrenia are effective, but also can reduce schizophrenia associated with depression, anxiety and cognitive deficits symptoms. Quetiapine is a novel phenothiazine antipsychotic, which is an antagonist of various neurotransmitter receptors in the brain and can block various neurotransmitter receptors in the brain. Its mechanism is mainly through blocking the D1, D2, 5-HT2A and other receptors of central dopamine. The affinity with 5-HT2 receptor is stronger than D1 and D2, and the binding ratio with 5-HT receptor and DA receptor is Chemicalbook2, which is the highest among atypical antipsychotics. It is also the atypical antipsychotic that blocks DA receptors least. D2 receptor blocking has been associated with extrapyramidal (EPS) symptoms, and preclinical studies have shown few EPS responses. Compared with the typical antipsychotic haloperidol, quetiapine significantly reduced the incidence of motor system disorders and hyperprolactinemia, and caused little or no dystonia in haloperidol sensitive monkeys, indicating a low incidence of tarDA dyskinesia (TD). It also blocks epinephrine alpha1 and histamine H1 receptors. Quetiapine has little affinity for cholinergic M receptors. Tests for antipsychotic activity such as the conditioned avoidance reflex came back positive.

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